Exploration of co-delivered drug micro-nanomotors and applications
Combined drug delivery micro-nanomotors refer to micron or nanoscale artificial robots driven by themselves or external energy, which can realize the combined delivery of multiple drugs in or in vivo, thus improving the therapeutic effect of drugs and reducing the side effects. These micro-nanomotors can be designed using different materials, shapes, functions, or response mechanisms to achieve the precise control and release of drugs. These micro-nanomotors have the advantages of high efficiency, flexibility, and can be used in various applications in the field of antitumor therapy. Case of combined delivery agent micro-nanomotors and application exploration: Ferriite nanoparticles (FNP) -based combined delivery micro-nanomotors enable magnetron movement and targeted delivery in life. FNP was loaded on a silicon-based carrier with hollow structure and pH responsiveness, and anticancer drugs and immunostimulants were loaded inside it to form combined delivery micro-nanomotors. Such micro-nanomotors can control their movement direction and speed through the external magnetic field, and release drugs and immunostimulants stimulated by the low pH in the tumor microenvironment, realizing the chemical killing or immune activation of tumor cells. Smatid (sperm cell) -based combined delivery micro-nanomotors enable light-controlled movement and targeted delivery in life. Sperm cells are wrapped in a polymer layer with photosensitivity and drug loading capacity, and anticancer drugs and photosensitizers are loaded in their interior to form combined drug delivery micro-nanomotors. Such micro-nanomotors can control the direction and speed of their movement by external laser, and release drugs and photosensitizers after reaching the target position, realizing the photodynamic treatment of cervical cancer cells. Combined micro-delivery (MOF) -based metal-organic frames enables sound-controlled motion and targeted delivery in life. MOF molecules are loaded on a silicon-based carrier with hollow structure and acoustic responsiveness, and anticancer drugs and oxidants are loaded inside them to form combined drug delivery micro-nanomotors. Such micro-nanomotors can control the direction and speed of their movement through external ultrasound wave, and release drugs and oxidants after reaching the target position, realizing chemical oxidative therapy for liver cancer cells.
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